Hypochlorite-induced aggregation of fibrinogen underlies a novel antioxidant role in blood plasma
نویسندگان
چکیده
Fibrinogen, a major constituent of blood plasma, is highly susceptible to reaction with biological oxidants. It has been proposed that fibrinogen plays role in antioxidant defence, but oxidation also known disrupt normal clotting and implicated the pathology atherosclerosis. In present study, we show oxidant hypochlorite promotes formation soluble high molecular weight assemblies ≥40 × 106 Da, do not accumulate when induced aggregate by other stresses such as heating or hydroxyl-mediated damage vitro. Hypochlorite-modified stable at 37 °C assessed precipitation assays, reduced susceptibility iron-induced (hydroxyl-mediated) compared native fibrinogen. contrast hypochlorite-modified albumin, which be immunostimulatory, does induce RAW 264.7 (macrophage-like) cells EOC 13.31 (microglia-like) produce reactive oxygen species cell death. Furthermore, depletion from human plasma increases immunostimulatory property after it supplemented situ. We propose potentially reduces accumulation albumin. The latter represent novel for defence.
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ژورنال
عنوان ژورنال: Redox biology
سال: 2021
ISSN: ['2213-2317']
DOI: https://doi.org/10.1016/j.redox.2020.101847